Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

Guewha Steven Huang*, Yu-Shiun Chen, Xin-Yau Lin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.
Original languageEnglish
Title of host publication2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3
PublisherIEEE
Pages7-10
ISBN (Print)978-1-4244-0607-4
DOIs
StatePublished - 2007
Event2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China
Duration: 2 Aug 20075 Aug 2007

Conference

Conference2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
CountryChina
CityHong Kong
Period2/08/075/08/07

Keywords

  • Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility

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