We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.
|Title of host publication||2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3|
|State||Published - 2007|
|Event||2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China|
Duration: 2 Aug 2007 → 5 Aug 2007
|Conference||2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007|
|Period||2/08/07 → 5/08/07|
- Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility