Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

Guewha Steven Huang; Yu-Shiun Chen; Xin-Yau Lin

doi:10.1109/NANO.2007.4601129

Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

Guewha Steven Huang^*, Yu-Shiun Chen, Xin-Yau Lin

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

Original language	English
Title of host publication	2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3
Publisher	IEEE
Pages	7-10
ISBN (Print)	978-1-4244-0607-4
DOIs	https://doi.org/10.1109/NANO.2007.4601129
State	Published - 2007
Event	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China Duration: 2 Aug 2007 → 5 Aug 2007

Conference

Conference	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
Country	China
City	Hong Kong
Period	2/08/07 → 5/08/07

Keywords

Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility

Access to Document

10.1109/NANO.2007.4601129

Fingerprint Dive into the research topics of 'Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin'. Together they form a unique fingerprint.

Cite this

@inbook{b0186a001b9446a9a810a24b25103f49,

title = "Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin",

abstract = "We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.",

keywords = "Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility",

author = "Huang, {Guewha Steven} and Yu-Shiun Chen and Xin-Yau Lin",

year = "2007",

doi = "10.1109/NANO.2007.4601129",

language = "English",

isbn = "978-1-4244-0607-4",

pages = "7--10",

booktitle = "2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3",

publisher = "IEEE",

note = "null ; Conference date: 02-08-2007 Through 05-08-2007",

}

Huang, GS, Chen, Y-S & Lin, X-Y 2007, Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin. in 2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3. IEEE, pp. 7-10, 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Hong Kong, China, 2/08/07. https://doi.org/10.1109/NANO.2007.4601129

TY - CHAP

T1 - Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

AU - Huang, Guewha Steven

AU - Chen, Yu-Shiun

AU - Lin, Xin-Yau

PY - 2007

Y1 - 2007

N2 - We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

AB - We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

KW - Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility

U2 - 10.1109/NANO.2007.4601129

DO - 10.1109/NANO.2007.4601129

M3 - Chapter

SN - 978-1-4244-0607-4

SP - 7

EP - 10

BT - 2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3

PB - IEEE

Y2 - 2 August 2007 through 5 August 2007

ER -