Antibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteria

Sin Ge Wang, Yen Chun Chen, Yu-Chie Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15°C under irradiation by a near-infrared laser (λ = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.

Original languageEnglish
Pages (from-to)1405-1416
Number of pages12
JournalNanomedicine
Volume13
Issue number12
DOIs
StatePublished - 1 Jun 2018

Keywords

  • antibacterial agents
  • gold nanoparticles
  • multivalent interactions
  • near infrared (NIR)
  • photothermal
  • vancomycin
  • vancomycin-resistant Enterococci

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