Angiogenesis inhibitor epoxyquinol A: Total synthesis and inhibition of transcription factor NF-κB

Chaomin Li, Sujata Bardhan, Emily A. Pace, Mei-Chih Liang, Thomas D. Gilmore, John A. Porco

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

equation presented The asymmetric synthesis of the natural product (+)-epoxyquinol A (1) and related epoxyquinoid dimers, employing a cascade oxidation/ electrocyclization/Diels-Alder dimerization sequence, is reported. In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-κB.

Original languageEnglish
Pages (from-to)3267-3270
Number of pages4
JournalOrganic Letters
Volume4
Issue number19
DOIs
StatePublished - 19 Sep 2002

Fingerprint Dive into the research topics of 'Angiogenesis inhibitor epoxyquinol A: Total synthesis and inhibition of transcription factor NF-κB'. Together they form a unique fingerprint.

  • Cite this