Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization

Peng Hui Wang*, Wen Yuann Shyong, Chi Hung Lin, Yann Jang Chen, Feng Li Ywan, Hsiang Tai Chao, Chiou Chung Yuan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

OBJECTIVE: To use comparative genomic hybridization (CGH) to analyze frozen tissues from adenomyosis cases to discover and map genomic regions for chromosomal gains and losses. STUDY DESIGN: In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings. RESULTS: No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis. CONCLUSION: Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Volume24
Issue number1
StatePublished - 2002

Keywords

  • Adenomyosis
  • Genes
  • Genetic aberrations
  • Genomic hybridization
  • Uterine diseases

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