A rotator and synthesizer driven (RSD) frequency pre-calibration technique is proposed in this paper for the wireless body area network applications. To overcome the large carrier frequency offset (CFO) and sampling clock offset (SCO) due to a low-cost and low-precision reference clock, the CFO and SCO are estimated from the system downlink process. These estimated CFO and SCO values are provided to a rotator and a synthesizer for signal pre-processing. This RSD concept is evaluated in the proposed WiBoC OFDMA system. The tolerated CFO and SCO ranges are extended to 2.5x of existing wireless systems. This system is designed and simulated in a 90nm technology with 77.5 μW computation power overhead.