An NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery: In vitro and in vivo

Srivardhan Reddy Gayam, Parthiban Venkatesan, Yi Ming Sung, Shuo Yuan Sung, Shang Hsiu Hu, Hsin-Yun Hsu, Shu-Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The synthesis and characterization of an NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles (MSNPs) for on-command delivery applications has been described in this paper. Gatekeeping of MSNPs is achieved by the integration of mechanically interlocked rotaxane nanovalves on the surface of MSNPs. The rotaxane nanovalve system is composed of a linear stalk anchoring on the surface of MSNPs, an α-cyclodextrin ring that encircles it and locks the payload "cargo" molecules in the mesopores, and a benzoquinone stopper incorporated at the end of the stalk. The gate opening and controlled release of the cargo are triggered by cleavage of the benzoquinone stopper using an endogenous NQO1 enzyme. In addition to having efficient drug loading and controlled release mechanisms, this smart biocompatible carrier system showed obvious uptake and consequent release of the drug in tumor cells, could selectively induce the tumor cell death and enhance the capability of inhibition of tumor growth in vivo. The controlled drug delivery system demonstrated its use as a potential theranostic material.

Original languageEnglish
Pages (from-to)12307-12317
Number of pages11
JournalNanoscale
Volume8
Issue number24
DOIs
StatePublished - 28 Jun 2016

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