With the rapid development of the communication technology, the Internet plays a more and more important role in many applications of healthcare. In healthcare field, mental disorder treatment is an important topic, with cognitive behavioral therapy and biofeedback therapy as two emerging and noteworthy methods. A number of researches on the integrations of the Internet and mental healthcare have been proposed recently. Thus, this research aims at the development of an online treatment system for panic patients by combining the cognitive behavioral therapy, biofeedback therapy, and web technologies. The system provides a more convenient communication between patients and medical personnel. The essential treatments and some related information provided by the medical personnel can be downloaded or used online by the patients via a web-based interface. On the other hand, important information such as physiological data can also be uploaded to the server databases automatically. Therefore, considerable time on the treatments can be saved for both patients and therapists, and the medical costs can be highly reduced. The experimental results show that the curative effects of the mental disorder patients are highly depend on the physiological status. The results of this research are expected to provide useful insights for the field of mental disorder treatment.