An integrated approach for genome-wide gene expression analysis

Yuh-Jyh Hu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Since efficient and relatively cheap methods were developed for determining biosequences, a lot of biosequence data has been generated. As the main problem in molecular biology is the analysis of the data instead of the data acquisition, part of the study of computational biology is to extract all kinds of meaningful information from the sequences. Computer-assisted methods have become very important in analyzing biosequence data. However, most of the current computer-assisted methods are limited to finding motifs. Genes can be regulated in many ways, including combinations of regulatory elements. This research is aimed at developing a new integrated system for genome-wide gene expression analysis. This research begins with a new motif-finding method, using a new objective function combining multiple well defined components and an improved stochastic iterative sampling strategy. Combinatorial motif analysis is accomplished by constructive induction that analyzes potential motif combinations. We then apply standard inductive learning algorithms to generate hypotheses for different gene behaviors. A genome-wide gene expression analysis demonstrated the value of this novel integrated system.

Original languageEnglish
Pages (from-to)163-174
Number of pages12
JournalComputer Methods and Programs in Biomedicine
Volume65
Issue number3
DOIs
StatePublished - 16 May 2001

Keywords

  • Constructive induction
  • Decision tree
  • Gene regulation
  • Motifs

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