An implantable drug-delivery system on a chip

Meng Shiue Lee, Da Jeng Yao, Wen-Syang Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

An implantable system for drug delivery provides a new strategy for drug therapy, and typically involves a microfluidic chip produced with micro or nano-technology. Implantable systems have the flexibility to conform various schemes of drug release, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release profile. Such an implantable system is classified as allowing either controllable or uncontrollable drug release after implantation, so an active or passive delivery system respectively. The performance and related applications of these systems vary. The key points of each technology are highlighted such as performance, working principle, fabrication methods, and dimensional constrains. We here review the implantable drug-delivery system in current research with a focus on application and chip performance, and comparison for passive and active delivery system.

Original languageEnglish
Pages (from-to)1516-1524
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume15
Issue number15
DOIs
StatePublished - 1 Jun 2015

Keywords

  • Drug delivery
  • Implant
  • MEMS
  • Microfluidic

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