Alteration of endogenous antioxidant enzymes in naturally occurring hypertrophic cardiomyopathy

Chih-Sheng Lin*, Chang Yeu Liu, Yu Lin Sun, Ling Chu Chang, Yung Tsung Chiu, San Yuan Huang, Jyh Hung Lin, Ping Cheng Yang, Redman Chu, Mu Chiou Huang, Simon J.T. Mao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We have recently developed a porcine model with naturally occurring hypertrophic cardiomyopathy (HCM). Similar to humans, occluded intramural coronary artery and damaged mitochondria are frequently observed in these animals in which the disease is thought to be associated with the local ischemia of myocardium. In view of antioxidant functions involved in the ischemic injury, we measured the expression of endogenous antioxidant enzymes in the tissues with and without HCM. The results showed a significant increase of Cu,Zn-superoxide dismutase (SOD), but not Mn-SOD, and decrease of catalase (CAT) activities in the various areas of HCM hearts. It was demonstrated that SOD/CAT ratios in the HCM hearts were significantly higher than those in normals and were found to be dramatically correlated with the severity of cardiac hypertrophy. The altered SOD/CAT ratio was also consistent with increase in lipid damage. We hypothesize that the elevated SOD combined with an inadequate amount of H2O2 scavenging enzyme may lead HCM heart at oxidative stress risk. However, the pathogenic role of imbalanced antioxidant enzyme needs to be further explored.

Original languageEnglish
Pages (from-to)1253-1263
Number of pages11
JournalBiochemistry and Molecular Biology International
Volume43
Issue number6
DOIs
StatePublished - 1 Dec 1997

Keywords

  • Catalase
  • Cu,Zn-superoxide dismutase
  • Free radicals
  • Hypertrophic cardiomyopathy
  • Mitochondria
  • Mn-superoxide dismutase
  • Oxidative stress

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