Aerobic oxidation of cyclohexane using N-hydroxyphthalimide bearing fluoroalkyl chains

Samar Kumar Guha, Yasushi Obora, Daisuke Ishihara, Hiroshi Matsubara, Ilhyong Ryu, Yasutaka Ishii*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The N-hydroxyphthalimide derivatives, F15-and F 17-NHPI, bearing a long fluorinated alkyl chain, were prepared and their catalytic performances were compared with that of the parent compound, N-hydroxyphthalimide (NHPI). The oxidation of cyclohexane under 10 atm of air in the presence of fluorinated F15-or F17-NHPI, cobalt diacetate [Co(OAc)2], and manganese diacetate [Mn(OAc)2] without any solvent at 100°C afforded a mixture of cyclohexanol and cyclohexanone (K/A oil) as major products along with a small amount of adipic acid. It was found that F15-and F17-NHPI exhibit higher catalytic activity than NHPI for the oxidation of cyclohexane without a solvent. However, for the oxidation in acetic acid all of these catalysts afforded adipic acid as a major product in good yield and the catalytic activity of NHPI in acetic acid was almost the same as those of F15-and F 17-NHPI. The oxidation by F15-and F17-NHPI catalysts in trifluorotoluene afforded K/A oil in high selectivity with little formation of adipic acid, while NHPI was a poor catalyst under these conditions, forming K/A oil as well as adipic acid in very low yields. The oxidation in trifluorotoluene by F15-and F17-NHPI catalysts was considerably accelerated by the addition of a small amount of zirconium(IV) acetylacetonate [Zr(acac)4] to the present catalytic system to afford selectively K/A oil, but no such effect was observed in the NHPI-catalyzed oxidation in trifluorotoluene.

Original languageEnglish
Pages (from-to)1323-1330
Number of pages8
JournalAdvanced Synthesis and Catalysis
Volume350
Issue number9
DOIs
StatePublished - 9 Jun 2008

Keywords

  • Aerobic oxidation
  • Cyclohexane
  • Fluorinated N-hydroxyphthalimide
  • K/A oil

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