Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

Chieh Wen Chung, May Jywan Tsai, Peng Wei Lin, Ding Wen Huang, Kuan Hsun Wang, Yu An Chen, Hsin-Fei Meng*, Hsiao-Wen Zan, Henrich Cheng, Limin Tong, Lei Zhang, Sheng Fu Horng, Cheng Hsiung Hung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.

Original languageEnglish
Article number025207
JournalAIP Advances
Volume8
Issue number2
DOIs
StatePublished - 1 Feb 2018

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