The healing process of chronic wounds (CWs) may last for weeks or even months. The process of CW healing relies on many highly regulated factors, such as C-reactive protein (CRP), uric acid (UA), and temperature, which require in-depth observations. Recently, multimodality electrochemistry has been used to acquire biological information pertaining to DNA sequencing , neurochemistry research  , and glucose monitoring . Wound monitoring bandages integrated with modality sensors can provide a comprehensive understanding of the wound healing status . Electrical stimulation has shown several advantages for CW healing, such as increasing the angiogenic response and antibacterial effects, during each healing phase . The temperature index is used to measure the inflammation of the wound. Figure 18.4.1 shows the diagram of the wound healing monitoring bandage. To acquire a large range of biomarkers, the electrochemical instrument must have an extensive operational range, use various scanning methodologies, require low power consumption, and provide high detection resolutions. This work presents a CMOS multimodality system-on-a-chip (SoC) integrated with electrochemical sensors (ECH), a temperature sensor (TS), and a current stimulator (CS).