A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement

Siang Sin Shan, Shao Yung Lu, Yuan Po Yang, Shu Ping Lin, Patrick Carey, Minghan Xian, Fan Ren, Stephen Pearton, Chin Wei Chang, Jenshan Lin, Yu Te Liao

Research output: Contribution to journalArticlepeer-review

Abstract

This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2 and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.

Original languageEnglish
Pages (from-to)1362-1370
Number of pages9
JournalIEEE Transactions on Biomedical Circuits and Systems
Volume14
Issue number6
DOIs
StatePublished - 1 Dec 2020

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