A switch-on MRI contrast agent for noninvasive visualization of methylmercury

Gyan Singh, Kuang Mei Hsu, Yu Jen Chen, Shou Cheng Wu, Chiao Yun Chen*, Yun-Ming Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This communication presents the first Gd(iii)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg+. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg+. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg+. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg+ and could be useful for biomedical applications.

Original languageEnglish
Pages (from-to)12032-12035
Number of pages4
JournalChemical Communications
Volume51
Issue number60
DOIs
StatePublished - 4 Aug 2015

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