A switch-on MRI contrast agent for noninvasive visualization of methylmercury

Gyan Singh; Kuang Mei Hsu; Yu Jen Chen; Shou Cheng Wu; Chiao Yun Chen; Yun-Ming Wang

doi:10.1039/c5cc01723h

A switch-on MRI contrast agent for noninvasive visualization of methylmercury

Gyan Singh, Kuang Mei Hsu, Yu Jen Chen, Shou Cheng Wu, Chiao Yun Chen^*, Yun-Ming Wang

^*Corresponding author for this work

Institute of Molecular Medicine and Bioengineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This communication presents the first Gd(iii)-based T₁ MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH₃Hg⁺. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH₃Hg⁺. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH₃Hg⁺. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH₃Hg⁺ and could be useful for biomedical applications.

Original language	English
Pages (from-to)	12032-12035
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	60
DOIs	https://doi.org/10.1039/c5cc01723h
State	Published - 4 Aug 2015

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title = "A switch-on MRI contrast agent for noninvasive visualization of methylmercury",

abstract = "This communication presents the first Gd(iii)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg+. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg+. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg+. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg+ and could be useful for biomedical applications.",

author = "Gyan Singh and Hsu, {Kuang Mei} and Chen, {Yu Jen} and Wu, {Shou Cheng} and Chen, {Chiao Yun} and Yun-Ming Wang",

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AU - Hsu, Kuang Mei

AU - Chen, Yu Jen

AU - Wu, Shou Cheng

AU - Chen, Chiao Yun

AU - Wang, Yun-Ming

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