A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes

F. C. Chien, Shean-Jen Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

Original languageEnglish
Pages (from-to)633-642
Number of pages10
JournalBiosensors and Bioelectronics
Volume20
Issue number3
DOIs
StatePublished - 15 Oct 2004

Keywords

  • Biomolecular interaction analysis
  • Conventional surface plasmon resonance
  • Coupled plasmon-waveguide resonance
  • Long-range surface plasmon resonance
  • Waveguide-coupled surface plasmon resonance

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