A pyrene-based highly selective turn-on fluorescent sensor for copper(II) ions and its application in living cell imaging

Hsuan Fu Wang, Shu-Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A new pyrene derivative (1) containing a benzothiazolenhydrazone moiety exhibited high selectivity for Cu2+ detection. In the presence of Cu2+, chemosensor 1 provided significant fluorescence enhancement, while Ag+, Ca2+, Cd2+, Co2+, Fe 2+, Fe3+, Hg2+, K+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+ metal ions produced only minor changes in fluorescence intensity. The association constant (Ka) for Cu2+ binding to 1 had a value of 5.00 × 108 M-2. The maximum fluorescence enhancement induced by Cu2+ binding to the chemosensor was observed over the range pH 2-8.5. Our fluorescence microscopy experiments demonstrate that chemosensor 1 may have application as a fluorescent probe for detecting Cu 2+ in living cells.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume181
DOIs
StatePublished - 25 Mar 2013

Keywords

  • Copper
  • Imaging agents
  • Pyrene
  • Sensors

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