A pyrene-based highly selective turn-on fluorescent chemosensor for iron(III) ions and its application in living cell imaging

Peter Kun Chung, Shi Rong Liu, Hsuan Fu Wang, Shu-Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

A new pyrene-based chemosensor (1) exhibits excellent selectivity for Fe3+ ions over a wide range of tested metal ions Ag+, Ca2+, Cd2+, Co2+, Cu2+, Fe 2+, Hg2+, K+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+. The binding of Fe 3+ to chemosensor 1 produces an emission band at 507 nm due to the formation of a Py-Py*excimer that is induced by Fe3+-binding. The binding ratio of 1-Fe3+ was determined to be 1:1 from a Job plot. The association constant of 1-Fe3+ complexes was found to be 1.27 × 104 M-1 from a Benesi-Hildebrand plot. In addition, fluorescence microscopy experiments show that 1 can be used as a fluorescent probe for detecting Fe3+ in living cells.

Original languageEnglish
Pages (from-to)1139-1145
Number of pages7
JournalJournal of Fluorescence
Volume23
Issue number6
DOIs
StatePublished - 1 Nov 2013

Keywords

  • Imaging agents
  • Iron
  • Pyrene
  • Sensors

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