A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin

Thomas K. Ritter, Kwok-Kong Mong, Haitian Liu, Takuji Nakatani, Chi Huey Wong

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

The notoriously difficult glycosylation of vancomycin was tackled in a one-pot procedure. A number of oligosaccharides were synthesized and attached to the vancomycin aglycon to create a library of derivatives (see formula) to probe the effect of glycosylation on the antibiotic activity.

Original languageEnglish
Pages (from-to)4657-4660
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number38
DOIs
StatePublished - 6 Oct 2003

Keywords

  • Antibiotics
  • Carbohydrates
  • Glycosylation
  • Oligosaccharides
  • Vancomycin

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