A phased-array stimulator system for studying planar and curved cardiac activation wavefronts

Rashida A. Abbas, Shien-Fong Lin, David Mashburn, Junkai Xu, John P. Wikswo*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted demonstration experiments on isolated perfused rabbit hearts, which were stained with the voltage-sensitive dye, di-4-ANEPPS. The wavefronts were imaged using a laser and a charge-coupled device (CCD) camera. The stimulator and imaging systems have been used to characterize the relationship between wavefront velocity and fiber orientation. This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume55
Issue number1
DOIs
StatePublished - 1 Jan 2008

Keywords

  • Cardiac conduction velocity
  • Curved activation wavefronts
  • Multisite stimulation
  • Tissue anisotropy

Fingerprint Dive into the research topics of 'A phased-array stimulator system for studying planar and curved cardiac activation wavefronts'. Together they form a unique fingerprint.

  • Cite this