A pH and temperature sensing needle for muscle tissue ischemia monitoring

E. C. Liang, K. L. Tsou, Y. S. Huang, Y. T. Cheng*, S. H. Chen, Y. S. Chen, M. D. Chou, P. W. Wu, L. H. Lu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The paper presents an 18G medical needle, where a silicon micromachined probe containing Au/Cu-based resistive temperature and (IrOx)/AgCl-based sensors is embedded inside and exhibit a linear sensitivity of 0.104Ω/°C and -57.4mV/pH, respectively. The needle is designated for real-time monitor the muscle tissue ischemia resulting from peripheral arterial occlusion. As compared with the lactate dehydrogenase (LDH) concentration change in the animal blood, the animal experimental results have shown that the real-time detected pH value and temperature within the muscle tissue can not only reflect actual muscle conditions with the composition change of interstitial tissue fluid but also differentiate the animal limbs with/without the peripheral arterial ligation.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1999-2001
Number of pages3
ISBN (Electronic)9781510897571
StatePublished - 1 Jan 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duration: 11 Nov 201815 Nov 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan
CityKaohsiung
Period11/11/1815/11/18

Keywords

  • Ischemia
  • Monitoring
  • Muscle tissue
  • PH sensor
  • Sensing needle

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