A panel of eight microRNAs is a good predictive parameter for triple-negative breast cancer relapse

Hsiao-Chin Hong, Cheng-Hsun Chuang, Wei-Chih Huang, Shun-Long Weng, Chia-Hung Chen, Kuang-Hsin Chang, Kuang-Wen Liao*, Hsien-Da Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Rationale: Triple-negative breast cancer (TNBC), which has the highest recurrence rate and shortest survival time of all breast cancers, is in urgent need of a risk assessment method to determine an accurate treatment course. Recently, miRNA expression patterns have been identified as potential biomarkers for diagnosis, prognosis, and personalized therapy. Here, we investigate a combination of candidate miRNAs as a clinically applicable signature that can precisely predict relapse in TNBC patients after surgery.

Methods: Four total cohorts of training (TCGA_TNBC and GEOD-40525) and validation (GSE40049 and GSE19783) datasets were analyzed with logistic regression and Gaussian mixture analyses. We established a miRNA signature risk model and identified an 8-miRNA signature for the prediction of TNBC relapse.

Results: The miRNA signature risk model identified ten candidate miRNAs in the training set. By combining 8 of the 10 miRNAs (miR-139-5p, miR-10b-5p, miR-486-5p, miR-455-3p, miR-107, miR-146b-5p, miR-324-5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). Subsequently, this 8-miRNA signature prognosticated relapse in the two validation sets with AUCs of 0.89 and 0.90.

Conclusion: The 8-miRNA signature predictive model may help clinicians provide a prognosis for TNBC patients with a high risk of recurrence after surgery and provide further personalized treatment to decrease the chance of relapse.

Original languageEnglish
Pages (from-to)8771-8789
Number of pages19
JournalTheranostics
Volume10
Issue number19
DOIs
StatePublished - Jan 2020

Keywords

  • triple-negative breast cancer
  • miRNA signature
  • relapse
  • prediction
  • prognosis
  • TUMOR RELAPSE
  • EXPRESSION
  • BIOMARKERS
  • SIGNATURE
  • SURVIVAL
  • IDENTIFICATION
  • MIR-146B-5P
  • PROGNOSIS
  • DIAGNOSIS
  • PROFILES

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