A new pyrene-based aggregation induced ratiometric emission probe for selective detections of trivalent metal ions and its living cell application

Ashutosh Singh, Ravinder Singh, Muthaiah Shellaiah, Epperla Chandra Prakash, Huan Cheng Chang, Putikam Raghunath, Ming-Chang Lin, Hong-Cheu Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

We synthesize a newly designed pyrene-based fluorescent probe FBP containing a Schiff base and amide linkage as a receptor, which demonstrates selective UV-vis and fluorometric detections of trivalent metal ions in various semi-aqueous solution conditions. Interestingly, by increasing water contents the aggregation induced ratiometric emissions (AIREs) of photoluminescence in FBP solutions (in DMSO/H2O) are enhanced from blue to green due to the excimer formation of the aggregates in water. In addition, the enhanced aggregated ratiometric green fluorescence behaviors of FBP in the presence of trivalent metal ions (Al3+, Fe3+, and Cr3+) are observed in semi-aqueous solutions as well as the solid state, which is well utilized to detect trivalent metal ions in living cells. Further verification of the probe detections, their interactions toward trivalent metal ions are well characterized by the time-resolved photoluminescence (TRPL) of spectroscopic responses as well as theoretical calculations. Therefore, we believe the application of such a new AIRE-based approach is first reported among Schiff base and pyrene-based fluorescent chemo- and bio-sensors.

Original languageEnglish
Pages (from-to)338-345
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume207
Issue numberPart A
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Aggregation induced ratiometric emission
  • Pyrene-based sensor
  • Schiff base
  • Trivalent sensor

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