A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite

Ku Kuei Lin, Shou Cheng Wu, Kuang Mei Hsu, Chen Hsiung Hung, Wen Feng Liaw, Yun-Ming Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO-) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection.

Original languageEnglish
Pages (from-to)4242-4245
Number of pages4
JournalOrganic Letters
Volume15
Issue number16
DOIs
StatePublished - 16 Aug 2013

Fingerprint Dive into the research topics of 'A N-(2-aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic amide (Ds-DAB) based fluorescent chemosensor for peroxynitrite'. Together they form a unique fingerprint.

Cite this