A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound

Hsin Yang Huang, Hao Li Liu, Po Hung Hsu, Chih Sheng Chiang, Chih Hung Tsai, Huei Shang Chi, San-Yuan Chen*, You Yin Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

(Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalAdvanced Materials
Volume27
Issue number4
DOIs
StatePublished - 27 Jan 2015

Keywords

  • Brainâ-blood barrier
  • Focused ultrasound
  • Magnetic guidance
  • Nanobubbles

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