A multiscale approach for surface-enhanced Raman spectroscopy (SERS) spectrum representation and its application to bacterial discrimination

Tsung Heng Tsai*, Ting Ting Liu, Yung Ching Huang, Yu Chen, Tian Jiun Liu, You Hsuan Lin, Chi Hung Lin, Yuh Lin Wang, Juen Kai Wang, Da Wei Wang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

A multiscale approach for peak representation and identification is proposed in the context of surface-enhanced Raman spectroscopy (SERS). The SERS spectrum is naturally composed of peaks with different preferred scales, and some tiny but reproducible peaks can be important distinguishing factors. However, if only a single scale is employed, there is a significant probability that a tiny peak will be overlooked because its preferred scale might be far away from the chosen scale. In contrast to many established approaches, the proposed method is able to adaptively characterize each peak on its preferred scale so that relevant information is not overlooked. We demonstrate the merit and biological relevance of multiscale peak identification with spectra from real biological experiments. In addition, the practicability of the proposed approach is evaluated on two bacterial discrimination tasks. The proposed method outperforms the single-scale approach, which is optimized trial-by-trial in the experiments.

Original languageEnglish
Title of host publicationBioMedical Engineering and Informatics
Subtitle of host publicationNew Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Pages328-333
Number of pages6
DOIs
StatePublished - 2008
EventBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - Sanya, Hainan, China
Duration: 27 May 200830 May 2008

Publication series

NameBioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Volume2

Conference

ConferenceBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
CountryChina
CitySanya, Hainan
Period27/05/0830/05/08

Fingerprint Dive into the research topics of 'A multiscale approach for surface-enhanced Raman spectroscopy (SERS) spectrum representation and its application to bacterial discrimination'. Together they form a unique fingerprint.

Cite this