A minimum-cost strategy for cluster recruitment

Wenyaw Chan*, NanFu Peng

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

It is becoming increasingly common for the design of a clinical study to involve cluster samples. Very few researches investigated the appropriate number of clusters. None of them treat cluster size and the number of clusters as random variables. In reality, the recruitment of clusters can not be reached at one time and the cluster sizes are usually random. The longer the recruitment takes the more expensive the total study costs will be. This paper provides a strategy for sequential recruitment of clusters, which can minimize the total study cost. By treating the number of additional observational subjects required at each time point as a Markov Chain, we derive an iterative procedure for optimal strategy and study the property of this strategy, especially the duration of the cluster recruitment. This strategy is also extended to search for an optimal number of centers in a multi-center clinical trial.

Original languageEnglish
Pages (from-to)877-886
Number of pages10
JournalBiometrical Journal
Volume42
Issue number7
DOIs
StatePublished - 1 Jan 2000

Keywords

  • Cluster sample
  • Markov chain
  • Principle of optimality
  • Sequential method

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