A mild and general method for preparation of α-glycosyl chlorides

Chih Wei Chang, Shih Sheng Chang, Chin Sheng Chao, Kwok-Kong Mong*

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A mild and efficient chlorination method for production of glycosyl chlorides is first described which employs inexpensive trichlorotriazine (TCT) and DMF as a chlorination reagent and is compatible with typical acid-labile hydroxyl protecting functions. The scope and limitations, reaction mechanism and its application in the sequential glycosylations are discussed.

Original languageEnglish
Pages (from-to)4536-4540
Number of pages5
JournalTetrahedron Letters
Volume50
Issue number31
DOIs
StatePublished - 5 Aug 2009

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