A microfluidic chip integrated with molecular imprinting polymers for surface plasmon resonance detection

Shih Chiang Huang*, Fan Ching Chien, Jan Sheng Lin, Shean-Jen Chen, Wen Janq Chen, Gwo Bin Lee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

This paper reports a novel microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps/microvalves to sensing regions where multiple MIP films are locally deposited such that highly-sensitive, highly-specific bio-sensing could be achieved. With the help of SPR sensing techniques, the microfluidic biochips have the potential to be widely used for bio-sensing applications. While compared to other sensing techniques, the developed system has several advantages, including labeling-free, high sensitivity, capability of quantitative analysis of nano-scale bio-molecules in real-time fashion.

Original languageEnglish
Title of host publicationTRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers
Pages1776-1779
Number of pages4
DOIs
StatePublished - 9 Nov 2005
Event13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05 - Seoul, Korea, Republic of
Duration: 5 Jun 20059 Jun 2005

Publication series

NameDigest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05
Volume2

Conference

Conference13th International Conference on Solid-State Sensors and Actuators and Microsystems, TRANSDUCERS '05
CountryKorea, Republic of
CitySeoul
Period5/06/059/06/05

Keywords

  • Microfluidic
  • Micropumps
  • MIP
  • SPR

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    Huang, S. C., Chien, F. C., Lin, J. S., Chen, S-J., Chen, W. J., & Lee, G. B. (2005). A microfluidic chip integrated with molecular imprinting polymers for surface plasmon resonance detection. In TRANSDUCERS '05 - 13th International Conference on Solid-State Sensors and Actuators and Microsystems - Digest of Technical Papers (pp. 1776-1779). [3E4.120] (Digest of Technical Papers - International Conference on Solid State Sensors and Actuators and Microsystems, TRANSDUCERS '05; Vol. 2). https://doi.org/10.1109/SENSOR.2005.1497437