A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells

Yu Ling Lin, Yen Ku Liu, Nu Man Tsai, Jui Hung Hsieh, Chia Hung Chen, Ching Min Lin, Kuang-Wen Liao*

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

A cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of hydrophobic curcumin to give curcumin/LPPC. Curcumin/LPPC had an average size less than 270 nm and a zeta potential of approximately 40 mV. The LPPC encapsulation efficiency for curcumin was about 45%. The authors found it surprising that the cytotoxic activity of the curcumin/LPPC was fivefold higher than curcumin when tested on curcumin-sensitive cells and 20-fold more active against curcumin-resistant cells. Curcumin/LPPC treatment caused a cell cycle arrest at G2/M phase, which rapidly resulted in apoptosis. The increased cytotoxic activity of curcumin/LPPC is likely attributable to its rapid accumulation in the cell. In vivo, administration of curcumin/LPPC inhibited about 60 - 90% of tumor growth in mice bearing CT-26 or B16F10 cells. These results demonstrate LPPC encapsulation technology is able to enhance the effects of antitumor drugs. Use of this technology may provide a new tool for cancer therapy, especially for drug-resistant cancer. From the Clinical Editor: This team of investigators used a cationic liposome-PEG-PEI complex (LPPC) to encapsulate curcumin. The different delivery method resulted in the five-fold increase of cytotoxic activity against curcumin-sensitive cells and twenty-fold against curcumin-resistant cells.

Original languageEnglish
Pages (from-to)318-327
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue number3
DOIs
StatePublished - 1 Apr 2012

Keywords

  • Antitumor
  • Apoptosis
  • Curcumin
  • Cytotoxicity
  • Lipo-PEG-PEI complex

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