A highly selective fluorescent sensor for Hg(ii) based on an NTe2 chelating motif and its application to living cell imaging

Shao Lun Kao, Parthiban Venkatesan, Shu Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A fluorescent probe (NBDTe) based on an NTe2 chelating motif has been developed for the highly selective and sensitive detection of Hg2+. Significant fluorescence enhancement was observed with the chemosensor NBDTe in the presence of Hg2+. Moreover, the metal ions Ag+, Al3+, Ca2+, Cd2+, Co2+, Cu2+, Cr3+, Fe2+, Fe3+, Hg2+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+ produced only minor changes in the fluorescence values of the system. The association constant (Ka) of Hg2+ binding to the chemosensor NBDTe was found to be 3.81 × 103 M-1, with a detection limit of 4.2 μM. The maximum fluorescence enhancement caused by Hg2+ binding to the chemosensor NBDTe was observed over the pH range of 4.0-10.0. In addition, fluorescence microscopy experiments showed that the chemosensor NBDTe can be used as a fluorescent probe for detecting Hg2+ in living cells.

Original languageEnglish
Pages (from-to)3551-3557
Number of pages7
JournalNew Journal of Chemistry
Volume39
Issue number5
DOIs
StatePublished - 1 May 2015

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