A highly efficient route to taxotere by the β-Lactam Synthon Method

Iwao Ojima*, Chung-Ming Sun, Martine Zucco, Young Hoon Park, Olivier Duclos, Scott Kuduk

*Corresponding author for this work

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Taxotère, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

Original languageEnglish
Pages (from-to)4149-4152
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number26
DOIs
StatePublished - 25 Jun 1993

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