A high-speed dual-phase domino circuit design with high performance and reliable characteristics is proposed. The cell-based automatic synthesis flow supports the quick design of high performance chips. The test chip of a dual-phase 64-bit high-speed multiplier with a built-in performance adjustment mechanism has been successfully validated using TSMC 0.18um CMOS technology. The test chip shows a 2.7X performance improvement compared to the conventional static CMOS logic design. In addition, a cell-based synthesizable design CAD flow, with consideration of the skew-tolerant issue has been established. A latched type domino cell library with noise-alleviation, charge sharing, and crosstalk alleviation abilities was also developed to support the proposed design flow. Finally, a built-in performance adjustment mechanism is conducted within the design. This mechanism supports performance adjustment after chip fabrication, under clock skew considerations.