A high-sensitivity CMOS-compatible biosensing system based on absorption photometry

Yu Wei Chang; Ping Chun Yu; Yang Tung Huang; Yuh-Shyong Yang

doi:10.1109/JSEN.2008.2011079

A high-sensitivity CMOS-compatible biosensing system based on absorption photometry

Yu Wei Chang^*, Ping Chun Yu, Yang Tung Huang, Yuh-Shyong Yang

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P⁺/N_well finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-μm CMOS technology. The ABTS/H₂O₂/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H ₂O₂, glucose, and histamine are 1 μM, 1 μM, and 10 μM, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.

Original language	English
Article number	4749398
Pages (from-to)	120-127
Number of pages	8
Journal	IEEE Sensors Journal
Volume	9
Issue number	2
DOIs	https://doi.org/10.1109/JSEN.2008.2011079
State	Published - 1 Feb 2009

Keywords

Biomedical transducers
CMOS analog integrated circuits
Medical diagnosis
Optical receivers

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title = "A high-sensitivity CMOS-compatible biosensing system based on absorption photometry",

abstract = "An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-μm CMOS technology. The ABTS/H2O2/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H 2O2, glucose, and histamine are 1 μM, 1 μM, and 10 μM, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.",

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