A high-sensitivity CMOS-compatible biosensing system based on absorption photometry

Yu Wei Chang*, Ping Chun Yu, Yang Tung Huang, Yuh-Shyong Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-μm CMOS technology. The ABTS/H2O2/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H 2O2, glucose, and histamine are 1 μM, 1 μM, and 10 μM, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.

Original languageEnglish
Article number4749398
Pages (from-to)120-127
Number of pages8
JournalIEEE Sensors Journal
Issue number2
StatePublished - 1 Feb 2009


  • Biomedical transducers
  • CMOS analog integrated circuits
  • Medical diagnosis
  • Optical receivers

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