TY - JOUR
T1 - A high-sensitivity CMOS-compatible biosensing system based on absorption photometry
AU - Chang, Yu Wei
AU - Yu, Ping Chun
AU - Huang, Yang Tung
AU - Yang, Yuh-Shyong
PY - 2009/2/1
Y1 - 2009/2/1
N2 - An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-μm CMOS technology. The ABTS/H2O2/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H 2O2, glucose, and histamine are 1 μM, 1 μM, and 10 μM, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.
AB - An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-μm CMOS technology. The ABTS/H2O2/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H 2O2, glucose, and histamine are 1 μM, 1 μM, and 10 μM, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.
KW - Biomedical transducers
KW - CMOS analog integrated circuits
KW - Medical diagnosis
KW - Optical receivers
UR - http://www.scopus.com/inward/record.url?scp=68349130670&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2008.2011079
DO - 10.1109/JSEN.2008.2011079
M3 - Article
AN - SCOPUS:68349130670
VL - 9
SP - 120
EP - 127
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
SN - 1530-437X
IS - 2
M1 - 4749398
ER -