A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides

Shaheen K. Mulani, Jih Hwa Guh, Kwok-Kong Mong*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A general strategy for the synthesis of phenylethanoid glycosides (PhG) including echinacoside 1, acteoside 2, calceolarioside-A 3 and calceolarioside-B 4 is reported. The strategy features the application of low substrate concentration glycosylation and N-formyl morpholine modulated glycosylation methods for the construction of 1,2-trans β- and α-glycosidic bonds. The reported strategy does not invoke the use of the participatory acyl protecting function, which is incompatible with the ester function present in target PhG compounds. A preliminary study of the anti-proliferation properties of the PhG compounds 1-4 was performed; the acteoside 2 exhibited the best inhibition on the prostatic cancer cell proliferation. This journal is

Original languageEnglish
Pages (from-to)2926-2937
Number of pages12
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number18
DOIs
StatePublished - 14 May 2014

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