A dual-mode chemosensor: Highly selective colorimetric fluorescent probe for Cu2+ and F- ions

Duraisamy Udhayakumari, Sivan Velmathi*, Wei Chieh Chen, Shu-Pao Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


N-Phenylthiosemicarbazones (R1-R4) have been synthesized and characterized by various spectroscopic techniques. The sensors (R1-R4) exhibited highly selective and sensitive recognition toward Cu2+ and F- ions over other cations and anions via visual color change. Sensors showed a significant fluorescent enhancement toward Cu2+ in aqueous medium and found a sub-nanomolar detection limit with good quantum yield. R1 displayed high selectivity to Cu2+ over other interference ions with 89-fold fluorescence intensity enhancement upon the addition of 2 equiv. of Cu 2+. In addition, the turn-on fluorescent changes upon the addition of Cu2+, is also applied in cell imaging.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalSensors and Actuators, B: Chemical
StatePublished - 1 Dec 2014


  • Cell imaging
  • Color change
  • Dual sensor
  • Fluorescence enhancement
  • Thiosemicarbazones

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