A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

Takahide Fukuyama, Masutaka Shinmen, Satoshi Nishitani, Masaaki Sato, Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticle

391 Scopus citations

Abstract

The PdCl2(PPh3)2-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF6]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.

Original languageEnglish
Pages (from-to)1691-1694
Number of pages4
JournalOrganic Letters
Volume4
Issue number10
DOIs
StatePublished - 16 May 2002

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