A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

Takahide Fukuyama; Masutaka Shinmen; Satoshi Nishitani; Masaaki Sato; Ilhyong Ryu

doi:10.1021/ol0257732

A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

Takahide Fukuyama, Masutaka Shinmen, Satoshi Nishitani, Masaaki Sato, Ilhyong Ryu^*

^*Corresponding author for this work

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

393 Scopus citations

Abstract

The PdCl₂(PPh₃)₂-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF₆]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.

Original language	English
Pages (from-to)	1691-1694
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	10
DOIs	https://doi.org/10.1021/ol0257732
State	Published - 16 May 2002

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abstract = "The PdCl2(PPh3)2-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF6]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.",

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AU - Sato, Masaaki

AU - Ryu, Ilhyong

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