A CMOS-compatible optical biosensing system based on visible absorption spectroscopy

Yu Wei Chang*, Ping Chun Yu, Yang Tung Huang, Yuh-Shyong Yang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-μm CMOS technology. The ABTS/H2O2/HRP method is adopted as the ground for medical diagnosis. Experimental results demonstrate that the minimum concentration successfully detected for H2 O2 is 1 μM. The detection limit is one order of magnitude better than a traditional CMOS biosensor, and comparable to a commercial spectrophotometer.

Original languageEnglish
Title of host publicationIEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007
Pages1099-1102
Number of pages4
DOIs
StatePublished - 1 Dec 2007
EventIEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007 - Tainan, Taiwan
Duration: 20 Dec 200722 Dec 2007

Publication series

NameIEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007

Conference

ConferenceIEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007
CountryTaiwan
CityTainan
Period20/12/0722/12/07

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    Chang, Y. W., Yu, P. C., Huang, Y. T., & Yang, Y-S. (2007). A CMOS-compatible optical biosensing system based on visible absorption spectroscopy. In IEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007 (pp. 1099-1102). [4450320] (IEEE Conference on Electron Devices and Solid-State Circuits 2007, EDSSC 2007). https://doi.org/10.1109/EDSSC.2007.4450320