A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice

Chung-Yu Wu; Chi Kuan Tzeng; Shih Yun Huang; Fang Liang Chu; Chuan Chin Chiao; Yueh Chun Tsai; Jun Ohta; Toshihiko Noda

doi:10.1109/MWSCAS.2019.8885223

A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice

Chung-Yu Wu, Chi Kuan Tzeng, Shih Yun Huang, Fang Liang Chu, Chuan Chin Chiao, Yueh Chun Tsai, Jun Ohta, Toshihiko Noda

Institute of Electronics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A self-photovoltaics-powered CMOS 256-pixel implantable chip with wide image dynamic range and shared electrodes is proposed and fabricated for subretinal prostheses. The infra-red (IR) light is incident only on photovoltaic cells of the chip whereas the visible light is mainly incident on pixels. The proposed adaptive background cancellation circuit (ABCC) is adopted to increase the image dynamic range so that the subretinal chip can adapt for different surrounding illuminances. Moreover, the bi-directional sharing electrodes (BDSEs) is used to increase electrode size under the same chip area and boost the stimulation charges to 11.4 nC. The functions of the chip have been successfully validated with both electrical measurement and in vitro patch clamp experiments with the retinas of Rd1 mice.

Original language	English
Title of host publication	2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	29-32
Number of pages	4
ISBN (Electronic)	9781728127880
DOIs	https://doi.org/10.1109/MWSCAS.2019.8885223
State	Published - Aug 2019
Event	62nd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2019 - Dallas, United States Duration: 4 Aug 2019 → 7 Aug 2019

Publication series

Name	Midwest Symposium on Circuits and Systems
Volume	2019-August
ISSN (Print)	1548-3746

Conference

Conference	62nd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2019
Country	United States
City	Dallas
Period	4/08/19 → 7/08/19

Keywords

CMOS image sensor
implantable chip
subretinal prostheses

Access to Document

10.1109/MWSCAS.2019.8885223

Link to publication in Scopus

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Wu, C-Y., Tzeng, C. K., Huang, S. Y., Chu, F. L., Chiao, C. C., Tsai, Y. C., Ohta, J., & Noda, T. (2019). A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice. In 2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019 (pp. 29-32). [8885223] (Midwest Symposium on Circuits and Systems; Vol. 2019-August). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MWSCAS.2019.8885223

Wu, Chung-Yu ; Tzeng, Chi Kuan ; Huang, Shih Yun ; Chu, Fang Liang ; Chiao, Chuan Chin ; Tsai, Yueh Chun ; Ohta, Jun ; Noda, Toshihiko. / A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice. 2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 29-32 (Midwest Symposium on Circuits and Systems).

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title = "A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice",

abstract = "A self-photovoltaics-powered CMOS 256-pixel implantable chip with wide image dynamic range and shared electrodes is proposed and fabricated for subretinal prostheses. The infra-red (IR) light is incident only on photovoltaic cells of the chip whereas the visible light is mainly incident on pixels. The proposed adaptive background cancellation circuit (ABCC) is adopted to increase the image dynamic range so that the subretinal chip can adapt for different surrounding illuminances. Moreover, the bi-directional sharing electrodes (BDSEs) is used to increase electrode size under the same chip area and boost the stimulation charges to 11.4 nC. The functions of the chip have been successfully validated with both electrical measurement and in vitro patch clamp experiments with the retinas of Rd1 mice.",

keywords = "CMOS image sensor, implantable chip, subretinal prostheses",

author = "Chung-Yu Wu and Tzeng, {Chi Kuan} and Huang, {Shih Yun} and Chu, {Fang Liang} and Chiao, {Chuan Chin} and Tsai, {Yueh Chun} and Jun Ohta and Toshihiko Noda",

year = "2019",

month = aug,

doi = "10.1109/MWSCAS.2019.8885223",

language = "English",

series = "Midwest Symposium on Circuits and Systems",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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booktitle = "2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019",

note = "null ; Conference date: 04-08-2019 Through 07-08-2019",

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Wu, C-Y, Tzeng, CK, Huang, SY, Chu, FL, Chiao, CC, Tsai, YC, Ohta, J & Noda, T 2019, A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice. in 2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019., 8885223, Midwest Symposium on Circuits and Systems, vol. 2019-August, Institute of Electrical and Electronics Engineers Inc., pp. 29-32, 62nd IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2019, Dallas, United States, 4/08/19. https://doi.org/10.1109/MWSCAS.2019.8885223

A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice. / Wu, Chung-Yu; Tzeng, Chi Kuan; Huang, Shih Yun; Chu, Fang Liang; Chiao, Chuan Chin; Tsai, Yueh Chun; Ohta, Jun; Noda, Toshihiko.

2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 29-32 8885223 (Midwest Symposium on Circuits and Systems; Vol. 2019-August).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Wu, Chung-Yu

AU - Tzeng, Chi Kuan

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AU - Chu, Fang Liang

AU - Chiao, Chuan Chin

AU - Tsai, Yueh Chun

AU - Ohta, Jun

AU - Noda, Toshihiko

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AB - A self-photovoltaics-powered CMOS 256-pixel implantable chip with wide image dynamic range and shared electrodes is proposed and fabricated for subretinal prostheses. The infra-red (IR) light is incident only on photovoltaic cells of the chip whereas the visible light is mainly incident on pixels. The proposed adaptive background cancellation circuit (ABCC) is adopted to increase the image dynamic range so that the subretinal chip can adapt for different surrounding illuminances. Moreover, the bi-directional sharing electrodes (BDSEs) is used to increase electrode size under the same chip area and boost the stimulation charges to 11.4 nC. The functions of the chip have been successfully validated with both electrical measurement and in vitro patch clamp experiments with the retinas of Rd1 mice.

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Wu C-Y, Tzeng CK, Huang SY, Chu FL, Chiao CC, Tsai YC et al. A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice. In 2019 IEEE 62nd International Midwest Symposium on Circuits and Systems, MWSCAS 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 29-32. 8885223. (Midwest Symposium on Circuits and Systems). https://doi.org/10.1109/MWSCAS.2019.8885223