A case-control study of breast cancer in Taiwan - A low-incidence area

Po Sheng Yang, Tsen Long Yang, Chien Liang Liu, Cheng-Wen Wu Lee, Chen Yang Shen*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations


To investigate risk factors for breast cancer in Taiwan, a low-incidence area, a case-control study was conducted. This comprised 244 subjects with diagnosed and pathologically confirmed breast cancer (age range 20-80 years) and 450 female ophthalmology outpatients as controls. Univariate and multiple logistic regression analysis suggests that breast cancer in Taiwan is aetiologically similar to breast cancer in high to moderate-incidence areas. A family history of breast cancer appears to be the most important factor contributing to the risk of breast cancer (odds ratio = 4.69). The effect of reproductive hormones (represented by the years of history of menses in premenopausal women, odds ratio = 3.35; or the age at menarche in post-menopausal women, odds ratio = 2.67) plays a significant role in tumorigenesis. Breast feeding appears to be a particularly important protective factor in Taiwanese women (odds ratio = 0.57).

Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalBritish Journal of Cancer
Issue number5
StatePublished - 1 Jan 1997


  • Breast cancer
  • Breast feeding
  • Cancer predisposition
  • Epidemiology
  • Reproductive hormone
  • Risk factor

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