TY - JOUR
T1 - A BODIPY-based highly selective fluorescent chemosensor for Hg 2+ ions and its application in living cell imaging
AU - Vedamalai, Mani
AU - Wu, Shu-Pao
PY - 2012/2/1
Y1 - 2012/2/1
N2 - A new boron-dipyrromethene (BODIPY) derivative (FS1) containing two triazole units exhibits an enhanced fluorescence in the presence of Hg
2+ ions and a high selectivity for Hg
2+ ions over competing metal ions in methanol: Ag
+, Ca
2+, Cd
2+, Co
2+, Cu
2+, Fe
2+, Fe
3+, K
+, Mg
2+, Mn
2+, Ni
2+, Pb
2+, and Zn
2+ produced only minor changes in the fluorescence of FS1. The apparent dissociation constant (K
d) of FS1-Hg
2+ was found to be 62 μM. Moreover, fluorescence microscopy experiments showed that FS1 can be used as a fluorescent probe for detecting Hg
2+ ions in living cells. A new BODIPY-based fluorescence chemosensor FS1 shows high selectivity for Hg
2+ ions over other transition-metal ions. The fluorescence of FS1 was significantly enhanced in the presence of Hg
2+, with green emission, and the addition of other metal ions barely affected the fluorescence. This FS1 chemosensor is an effectivemethod for Hg
2+ sensing in living cellimaging.
AB - A new boron-dipyrromethene (BODIPY) derivative (FS1) containing two triazole units exhibits an enhanced fluorescence in the presence of Hg
2+ ions and a high selectivity for Hg
2+ ions over competing metal ions in methanol: Ag
+, Ca
2+, Cd
2+, Co
2+, Cu
2+, Fe
2+, Fe
3+, K
+, Mg
2+, Mn
2+, Ni
2+, Pb
2+, and Zn
2+ produced only minor changes in the fluorescence of FS1. The apparent dissociation constant (K
d) of FS1-Hg
2+ was found to be 62 μM. Moreover, fluorescence microscopy experiments showed that FS1 can be used as a fluorescent probe for detecting Hg
2+ ions in living cells. A new BODIPY-based fluorescence chemosensor FS1 shows high selectivity for Hg
2+ ions over other transition-metal ions. The fluorescence of FS1 was significantly enhanced in the presence of Hg
2+, with green emission, and the addition of other metal ions barely affected the fluorescence. This FS1 chemosensor is an effectivemethod for Hg
2+ sensing in living cellimaging.
KW - Fluorescence
KW - Imaging agents
KW - Mercury
KW - Sensors
UR - http://www.scopus.com/inward/record.url?scp=84863178635&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201101623
DO - 10.1002/ejoc.201101623
M3 - Article
AN - SCOPUS:84863178635
SP - 1158
EP - 1163
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1434-193X
IS - 6
ER -