A BODIPY-based colorimetric and fluorometric chemosensor for Hg(ii) ions and its application to living cell imaging

Mani Vedamalai, Shu-Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

A new monostyryl boron dipyrromethene derivative (MS1) appended with two triazole units indicates the presence of Hg2+ among other metal ions with high selectivity by color change and red emission. Upon Hg2+ binding, the absorption band of MS1 is blue-shifted by 29 nm due to the inhibition of the intramolecular charge transfer from the nitrogen to the BODIPY, resulting in a color change from blue to purple. Significant fluorescence enhancement is observed with MS1 in the presence of Hg 2+; the metal ions Ag+, Ca2+, Cd2+, Co2+, Cu2+, Fe2+, Fe3+, K +, Mg2+, Mn2+, Ni2+, Pb 2+, and Zn2+ cause only minor changes in the fluorescence of the system. The apparent association constant (Ka) of Hg 2+ binding in MS1 is found to be 1.864 × 105 M -1. In addition, fluorescence microscopy experiments show that MS1 can be used as a fluorescent probe for detecting Hg2+ in living cells.

Original languageEnglish
Pages (from-to)5410-5416
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number28
DOIs
StatePublished - 28 Jul 2012

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