A biosensor of high-density lipoprotein of human serum on a liquid crystal and polymer composite film

Yi-Hsin Lin*, Kai Han Chang, Wei Lin Chu, Yu Shih Tsou, Li Ching Wu, Chien Feng Li

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

A biosensor for the concentration of high-density lipoprotein (HDL) in human serum on a liquid crystal and polymer composite film (LCPCF) is demonstrated. The sensing mechanism is based on a polar-polar interaction between orientation of LC directors and HDL in human serum. The concentration of polar HDL in human serum affects the orientations of LC directors at the interface between LCPCF and the human serum. In addition, the surface free energy of LCPCF changes with the applied voltage due to the electrically tunable orientations of LC directors anchored among the polymer grains of LCPCF. As a result, the droplet motion of human serum on LCPCF under applied voltages can sense the concentration of HDL in human serum.

Original languageEnglish
Title of host publicationLiquid Crystals XVII
DOIs
StatePublished - 4 Nov 2013
EventLiquid Crystals XVII - San Diego, CA, United States
Duration: 25 Aug 201328 Aug 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8828
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceLiquid Crystals XVII
CountryUnited States
CitySan Diego, CA
Period25/08/1328/08/13

Keywords

  • Biosensor
  • High-density lipoprotein
  • Human serum.
  • Liquid crystals
  • Liquid-crystal devices

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