A 19 W, 50 kS/s, 0.008-400V/s Cyclic Voltammetry Readout Interface with a Current Feedback Loop and On-Chip Pattern Generation

Shao Yung Lu, Yu Te Liao

Research output: Contribution to journalArticlepeer-review

Abstract

A cyclic voltammetry electrochemical sensing chip was implemented with a time-based readout circuit and a current feedback control loop for wide-range and high-linearity current detection. The design utilizes a chopper-stabilized, low-noise potentiostat circuit and a delay chain time-to-digital converter to improve accuracy and the conversion rate. A current feedback loop is employed to mitigate nonlinearity of the current-to-frequency converter. Also, an on-chip pattern generator with a current reducer is used to create area-efficient, multi-rate ramp signals for cyclic voltammetry and fast-scan cyclic voltammetry measurements. The chip is fabricated using a 0.18-μm CMOS process. It achieves an 8-nA current resolution in the current range of -7 A to 10 A with an R2 linearity of 0.999 while consuming 19 W. The Allan deviation floor is 4.83 Hz at the 7-second integration window, resulting in an 87-pArms input-referred current noise. The applicable limit of detection for K3[Fe(CN)6] concentration is 31 pM. To measure various reactions, the scan rate can be adjusted from 0.008 V/s to 400 V/s with a throughput data rate of up to 50 kS/s.

Original languageEnglish
JournalIEEE Transactions on Biomedical Circuits and Systems
DOIs
StateAccepted/In press - 2021

Keywords

  • Current measurement
  • Delays
  • Electrodes
  • Frequency conversion
  • Generators
  • high data throughput
  • linearity
  • Linearity
  • on-chip pattern generator
  • potentiostat
  • Sensors

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