5-Phenylpyridazinones-A serendipitous route from coumarins

Manjunath D. Ghate, Vithal B. Jadhav, Lokesh A. Shastri, Manohar V. Kulkarni*, Geetha M. Kulkarni, Chih Hau Chen, Chung-Ming Sun

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations


A new route of the ring transformation has been discovered during the reaction of 4-bromomethylcoumarins with hydrazine hydrate leading to the formation of pharmacologically important pyridazinones in a single step with very high yields. These so obtained pyridazinones have the potential for further functional group interconversions.

Original languageEnglish
Pages (from-to)4394-4396
Number of pages3
JournalTetrahedron Letters
Issue number28
StatePublished - 7 Jul 2008

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    Ghate, M. D., Jadhav, V. B., Shastri, L. A., Kulkarni, M. V., Kulkarni, G. M., Chen, C. H., & Sun, C-M. (2008). 5-Phenylpyridazinones-A serendipitous route from coumarins. Tetrahedron Letters, 49(28), 4394-4396. https://doi.org/10.1016/j.tetlet.2008.05.015