5-Azahexenoyl radicals cyclize via nucleophilic addition to the acyl carbon rather than 5-exo homolytic addition at the imine

Chantal T. Falzon, Ilhyong Ryu, Carl H. Schiesser

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Molecular orbital calculations predict that the 5-azahexenoyl radical ring closes via nucleophilic addition to the acyl carbon to afford the 5-exo product; CCSD(T)/cc-pVDZ//BHLYP/cc-pVDZ calculations predict energy barriers of 36.1 and 46.9 kJ mol-1 for the exo and endo cyclization modes of the 5-azahexenoyl radical, respectively.

Original languageEnglish
Pages (from-to)2338-2339
Number of pages2
JournalChemical Communications
Volume20
DOIs
StatePublished - 1 Jan 2002

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