2-dimensional SPR detection system integrated with molecular imprinting polymer microarrays using microfluidic technology

Kuo Hoong Lee*, Yuan Deng Su, Shean-Jen Chen, Gwo B. Lee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

This paper reports a novel microfluidic chip integrated with arrayed molecular imprinting polymer (MIP) films for surface plasmon resonance (SPR) phase imaging of specific bio-samples. The SPR imaging system uses a surface-sensitive optical technique to detect two-dimensional spatial phase variation caused by bio-molecules absorbed on a sensing surface composed of highly-specific MIP films. The developed system has a high resolution and a high-throughput screening capability and has been successfully applied to the analysis of multiple bio-molecules without the need for additional labeling in long-term measuring. The innovative microfluidic chip is capable of transporting a specific amount of multiple bio-samples inside multiple microchannels using micropumps/microvalves to the sensing regions where arrayed MIP films are locally deposited such that highly-sensitive, highly-specific bio-sensing can be achieved.

Original languageEnglish
Title of host publication19th IEEE International Conference on Micro Electro Mechanical Systems
Pages430-433
Number of pages4
DOIs
StatePublished - 24 Oct 2006
Event19th IEEE International Conference on Micro Electro Mechanical Systems - Istanbul, Turkey
Duration: 22 Jan 200626 Jan 2006

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2006
ISSN (Print)1084-6999

Conference

Conference19th IEEE International Conference on Micro Electro Mechanical Systems
CountryTurkey
CityIstanbul
Period22/01/0626/01/06

Keywords

  • MEMS
  • Microfluidic
  • MIP
  • SPR

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    Lee, K. H., Su, Y. D., Chen, S-J., & Lee, G. B. (2006). 2-dimensional SPR detection system integrated with molecular imprinting polymer microarrays using microfluidic technology. In 19th IEEE International Conference on Micro Electro Mechanical Systems (pp. 430-433). [1627828] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2006). https://doi.org/10.1109/MEMSYS.2006.1627828