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Yu-Yuan Hsiao

Associate Professor

 https://orcid.org/0000-0002-9648-5879
20082020

Research output per year

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Personal profile

Research Interests

Structural Biology, Structure based drug design, Nucleic acid binding proteins

Experience

2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica

2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU

Education/Academic qualification

PhD, National Tsing Hua University

External positions

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Projects

闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)

Hsiao, Y.

1/02/20 → 31/01/21

Project: Government Ministry › Ministry of Science and Technology

闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)

Hsiao, Y.

1/02/19 → 30/04/20

Project: Government Ministry › Ministry of Science and Technology

Structure, Function, and Biomedical Applications of APE1

Hsiao, Y.

1/08/18 → 30/04/19

Project: Government Ministry › Ministry of Science and Technology

Molecular mechanisms and biomedical applications of TREX1 related cellular events

Hsiao, Y.

1/08/17 → 31/07/18

Project: Government Ministry › Ministry of Science and Technology

Structural Analysis and Antiviral Inhibitor Development for DnaQ-family Exonucleases

Hsiao, Y.

1/08/16 → 31/07/17

Project: Government Ministry › Ministry of Science and Technology

Research Output

Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity

Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 13 Mar 2020, In : Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.

Research output: Contribution to journal › Article

    • MOLECULAR MECHANISMS OF TREX1 IN DNA REPAIR AND IMMUNE SILENCING

    Huang, K-W., Liu, T-C. & Hsiao, Y-Y., 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. E101-E101 1 p.

    Research output: Contribution to journal › Meeting Abstract

    Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

    Huang, K. W., Liu, T. C., Liang, R. Y., Chu, L. Y., Cheng, H. L., Chu, J-W. & Hsiao, Y-Y., 7 May 2018, In : PLoS Biology. 16, 5, e2005653.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Structural insights into the duplex DNA processing of TREX2

    Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y-Y., 1 Jan 2018, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

    Huang, K. W., Hsu, K. C., Chu, L. Y., Yang, J-M., Yuan, H. S. & Hsiao, Y-Y., 8 Sep 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 8019-8029 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Prizes

    Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C

    Hsiao, Yu-Yuan (Recipient), 2013

    Prize: Honorary award

    Outstanding postdoctoral research award, National Science Council

    Hsiao, Yu-Yuan (Recipient), 2013

    Prize: Honorary award