Yu-Yuan Hsiao

Associate Professor

https://orcid.org/0000-0002-9648-5879

Phone03-5712121#56999
Emailmike0617@nctu.edu.tw
Websitehttp://life.nctu.edu.tw/~yyhsiao/index.html

Research activity per year

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Personal profile

Research Interests

Structural Biology, Structure based drug design, Nucleic acid binding proteins

Experience

2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica

2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU

Education/Academic qualification

PhD, National Tsing Hua University

External positions

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8 Finished

闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)
Hsiao, Y.
1/02/20 → 31/01/21
Project: Government Ministry › Ministry of Science and Technology
闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)
Hsiao, Y.
1/02/19 → 30/04/20
Project: Government Ministry › Ministry of Science and Technology
Structure, Function, and Biomedical Applications of APE1
Hsiao, Y.
1/08/18 → 30/04/19
Project: Government Ministry › Ministry of Science and Technology
Molecular mechanisms and biomedical applications of TREX1 related cellular events
Hsiao, Y.
1/08/17 → 31/07/18
Project: Government Ministry › Ministry of Science and Technology
Structural Analysis and Antiviral Inhibitor Development for DnaQ-family Exonucleases
Hsiao, Y.
1/08/16 → 31/07/17
Project: Government Ministry › Ministry of Science and Technology

17 Article
1 Meeting Abstract

APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
Liu, T. C., Lin, C. T., Chang, K. C., Guo, K. W., Wang, S., Chu, J. W. & Hsiao, Y. Y., Dec 2021, In: Nature Communications. 12, 1, 601.
Research output: Contribution to journal › Article › peer-review

Open Access
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 13 Mar 2020, In: Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.
Research output: Contribution to journal › Article › peer-review
MOLECULAR MECHANISMS OF TREX1 IN DNA REPAIR AND IMMUNE SILENCING
Huang, K-W., Liu, T-C. & Hsiao, Y-Y., 2019, In: Acta Crystallographica Section A: Foundations and Advances. 75, p. E101-E101 1 p.
Research output: Contribution to journal › Meeting Abstract › peer-review
Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Huang, K. W., Liu, T. C., Liang, R. Y., Chu, L. Y., Cheng, H. L., Chu, J-W. & Hsiao, Y-Y., 7 May 2018, In: PLoS Biology. 16, 5, 22 p., e2005653.
Research output: Contribution to journal › Article › peer-review

Open Access
9 Scopus citations
Structural insights into the duplex DNA processing of TREX2
Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y-Y., 1 Jan 2018, In: Nucleic acids research. 46, 22, p. 12166-12176 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations

Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award
Outstanding postdoctoral research award, National Science Council
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award