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Personal profile

Research Interests

Structural Biology, Structure based drug design, Nucleic acid binding proteins

Experience

2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica

2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU

Education/Academic qualification

PhD, National Tsing Hua University

External positions

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Projects

闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)

Hsiao, Y.

1/02/2031/01/21

Project: Government MinistryMinistry of Science and Technology

闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)

Hsiao, Y.

1/02/1930/04/20

Project: Government MinistryMinistry of Science and Technology

Structure, Function, and Biomedical Applications of APE1

Hsiao, Y.

1/08/1830/04/19

Project: Government MinistryMinistry of Science and Technology

Molecular mechanisms and biomedical applications of TREX1 related cellular events

Hsiao, Y.

1/08/1731/07/18

Project: Government MinistryMinistry of Science and Technology

Structural Analysis and Antiviral Inhibitor Development for DnaQ-family Exonucleases

Hsiao, Y.

1/08/1631/07/17

Project: Government MinistryMinistry of Science and Technology

Research Output

Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity

Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 13 Mar 2020, In : Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.

Research output: Contribution to journalArticle

  • MOLECULAR MECHANISMS OF TREX1 IN DNA REPAIR AND IMMUNE SILENCING

    Huang, K-W., Liu, T-C. & Hsiao, Y-Y., 2019, In : Acta Crystallographica Section A: Foundations and Advances. 75, p. E101-E101 1 p.

    Research output: Contribution to journalMeeting Abstract

    Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

    Huang, K. W., Liu, T. C., Liang, R. Y., Chu, L. Y., Cheng, H. L., Chu, J-W. & Hsiao, Y-Y., 7 May 2018, In : PLoS Biology. 16, 5, e2005653.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations

    Structural insights into the duplex DNA processing of TREX2

    Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y-Y., 1 Jan 2018, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations
    Open Access
  • 3 Scopus citations