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Personal profile

Research Interests

Natural prodcuts biosynthesis, enzyme engineering, structural biology


2011/09~2015/01 Postdoctoral Fellow, Genomics Research Center, Academia Sinica

2015/01~2018/03 Postdoctoral research associate, Department of Chemistry, The Scripps Research Institute

2018/04~2018/07 Researcher, Department of Bio-based Chemicals and Biocatalyst, Industrial Technology Research Institute

2018/8~ present Assistant Professor, Department of Biological Science and Technology, National Chiao Tung University

Education/Academic qualification

PhD, National Chiao Tung University

External positions

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Research Output

Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates

Adhikari, A., Teijaro, C. N., Yan, X., Chang, C. Y., Gui, C., Liu, Y. C., Crnovcic, I., Yang, D., Annaval, T., Rader, C. & Shen, B., 13 Aug 2020, In : Journal of Medicinal Chemistry. 63, 15, p. 8432-8441 10 p.

Research output: Contribution to journalArticle

  • Pregnenolonyl-α-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities

    Chou, F. P., Hsu, W. C., Huang, S. C., Chang, C. Y., Chiou, Y. S., Tsai, C. T., Lyu, J. W., Chen, W. T. & Wu, T. K., 7 Feb 2020, In : Chemical Communications. 56, 11, p. 1733-1736 4 p.

    Research output: Contribution to journalArticle

  • Terpene synthases in disguise: Enzymology, structure, and opportunities of non-canonical terpene synthases

    Rudolf, J. D. & Chang, C. Y., 1 Mar 2020, In : Natural Product Reports. 37, 3, p. 425-463 39 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    Genome mining and biosynthesis of kitacinnamycins as a STING activator

    Shi, J., Liu, C. L., Zhang, B., Guo, W. J., Zhu, J., Chang, C-Y., Zhao, E. J., Jiao, R. H., Tan, R. X. & Ge, H. M., 1 Jan 2019, In : Chemical Science. 10, 18, p. 4839-4846 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Multiple Pleomorphic Tetramers of Thermostable Direct Hemolysin from Grimontia hollisae in Exerting Hemolysis and Membrane Binding

    Wang, Y. K., Huang, S. C., Chang, C-Y., Huang, W. T., Liao, M. J., Yip, B. S., Chou, F. P., Li, T. T. H. & Wu, T-K., 8 Jul 2019, In : Scientific reports. 9, 1, 9833.

    Research output: Contribution to journalArticle

    Open Access