Projects per year
Organization profile
organization profile
Introduction to the Institute of Molecular Medicine and Bioengineering The expression of genes and the structures and the functions of the gene products such as RNAs and proteins regulate biological functions within the organisms. Dysregulation in these biological molecules caused from either external (such as microbes) or internal (such as tumors) factors may incur diseases in humans. Therefore detection and understanding the structural information and functional mechanisms of DNAs, RNAs, and proteins at the molecular level have become key research directions in molecular medicine in the 21st century. These knowledges are crucial for developing therapeutic methods that can regulate gene expressions and protein functions
The National Chiao Tung University is set to develop strategies that combine basic and applied sciences in response to the rapid evolution of knowledge and challenges from global sustainability in the 21st century. Within these strategies is a focus on cross-disciplinary researches between basic sciences, molecular medicine, and bioengineering. Furthermore, following the completion of the human genome maps, academic research and the biotechnology industry have entered the post-genome era. Basic researches in molecular medicine and bioengineering applications are expected to accelerate due to large amounts of genomic and proteomic information.
Based on the strategic plan of Chiao Tung University, the Institute of Molecular Medicine and Bioengineering (IMMB) was established and affiliated to the College of Biological Science and Technology in 2009. As an education and research institute, IMMB aims to train students with proficient knowledge in molecular mechanisms of cell physiology and disease pathogeneses. We also aim to cultivate student capable of integrating different fields such as molecular detection and biomaterials for leading-edge researches in basic and applied biomedical sciences.
We in IMMB inquire scientific knowledge in biomedicine and develop applications based on molecular and cellular biology. Our main research themes include exploration of physiology and pathology of cells and organisms from cellular and molecular level and developments of biomaterials for diagnosis and therapy. These research themes cover various scopes such as basic cell biology, structural biology, mechanisms of diseases, immunology, tumor biology, biological sensing and diagnosis, and nanomaterials. On the basis of past achievements, we will continue to deepen basic researches in molecular medicine and develop novel theranostic applications.
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Profiles
Projects
探討多功能磁振造影對比劑、多功能奈米金粒子及鐵金屬錯化合物用於早期診斷與治療癌症、阿茲海默症、生物探針開發之合成與特性研究
1/08/20 → 31/07/21
Project: Government Ministry › Ministry of Science and Technology
探討非小細胞肺癌PD-L1在PD-L1抗體藥物及EGFR-TKI藥物的療效與抗藥作用
1/08/20 → 31/07/21
Project: Government Ministry › Ministry of Science and Technology
研究神經細胞質中Ran的傳遞機制與其在神經元成熟與ALS致病機制中所扮演之角色(2/3)
1/08/20 → 31/07/21
Project: Government Ministry › Ministry of Science and Technology
Research Output
Actin waves transport RanGTP to the neurite tip to regulate non-centrosomal microtubules in neurons
Huang, Y. A., Hsu, C. H., Chiu, H. C., Hsi, P. Y., Ho, C. T., Lo, W. L. & Hwang, E., 14 May 2020, In : Journal of cell science. 133, 9Research output: Contribution to journal › Article
Open Access
Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma
Huang, Y. W., Lin, C. Y., Tsai, H. C., Fong, Y. C., Han, C. K., Huang, Y. L., Wu, W. T., Cheng, S. P., Chang, H. C., Liao, K. W., Wang, S. W. & Tang, C. H., 31 May 2020, In : Aging. 12, 10, p. 9475-9488 14 p.Research output: Contribution to journal › Article
Antitumor effects of n-butylidenephthalide encapsulated in lipopolyplexs in colorectal cancer cells
Chang, K. F., Chang, J. T., Huang, X. F., Lin, Y. L., Liao, K. W., Huang, C. W. & Tsai, N. M., May 2020, In : Molecules. 25, 10, 2394.Research output: Contribution to journal › Article
Open Access
Prizes
Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award
Excellent Teaching Award, National Chiao Tung University
Yuan, Chiun-Jye (Recipient), 2011
Prize: Honorary award
Excellent Teaching Award, National Chiao Tung University
Liao, Kuang-Wen (Recipient), 2011
Prize: Honorary award
Activities
- 1 Editorial work
Scientific Reports (Event)
Jui-I Chao (Member of editorial board)
1 Jan 2016 → 31 Dec 2018
Activity: Publication peer-review and editorial work › Editorial work